Immunogen
Synthesized peptide derived from human SCOT1 AA range: 105-155
Specificity
This antibody detects endogenous levels of SCOT1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.,disease:Defects in OXCT1 are a cause of ketoacidosis [MIM:245050].,function:Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.,pathway:Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.,similarity:Belongs to the 3-oxoacid CoA-transferase family.,subunit:Homodimer.,tissue specificity:Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.,
Gene Name
OXCT1 OXCT SCOT
Fields
>>Valine, leucine and isoleucine degradation;>>Butanoate metabolism;>>Metabolic pathways
Human protein sequence Database
P55809
Mouse protein sequence database
Q9D0K2
Rat protein sequence database
B2GV06
Cellular localization
Mitochondrion .
Tissue expression
Abundant in heart, followed in order by brain, kidney, skeletal muscle, and lung, whereas in liver it is undetectable. Expressed (at protein level) in all tissues (except in liver), most abundant in myocardium, then brain, kidney, adrenal glands, skeletal muscle and lung; also detectable in leukocytes and fibroblasts.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车