Immunogen
Synthesized peptide derived from human VCX3 AA range: 40-90
Specificity
This antibody detects endogenous levels of VCX3 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008],
Function
disease:Defects in VCX3A are associated with some forms of X-linked nonspecific mental retardation.,function:May mediate a process in spermatogenesis or may play a role in sex ratio distortion.,similarity:Belongs to the VCX/VCY family.,tissue specificity:Expressed exclusively in testis.,
Gene Name
VCX3A VCX3 VCX8R VCXA
Human protein sequence Database
Q9NNX9
Mouse protein sequence database
Rat protein sequence database
Cellular localization
nucleus,nucleolus,
Tissue expression
Expressed exclusively in testis.
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