Immunogen
Synthesized peptide derived from human D106A AA range: 1-51
Specificity
This antibody detects endogenous levels of D106A at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy. [provided by RefSeq, Oct 2014],
Function
function:Has antibacterial activity.,similarity:Belongs to the beta-defensin family.,tissue specificity:Expressed specifically in epididymis and lung.,
Gene Name
DEFB106A BD6 DEFB106 DEFB6; DEFB106B
Human protein sequence Database
Q8N104
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted . Membrane . Associates with tumor cell membrane-derived microvesicles (PubMed:23938203). .
Tissue expression
Expressed specifically in epididymis and lung.
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