Immunogen
Synthesized peptide derived from human GRIK3 AA range: 209-259
Specificity
This antibody detects endogenous levels of GRIK3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008],
Function
function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.,RNA editing:Partially edited.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Homomeric. Can also coassemble with either GRIK4 or GRIK5 to form heteromeric receptors. Interacts with PRKCABP.,
Fields
>>Neuroactive ligand-receptor interaction;>>Glutamatergic synapse
Human protein sequence Database
Q13003
Mouse protein sequence database
B1AS29
Rat protein sequence database
P42264
Cellular localization
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
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