Immunogen
Synthesized peptide derived from human LR16A AA range: 853-903
Specificity
This antibody detects endogenous levels of LR16A at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization.,similarity:Belongs to the CARMIL family.,similarity:Contains 11 LRR (leucine-rich) repeats.,subcellular location:Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers.,subunit:Interacts via its C-terminus with CAPZA2 in cytoplasm; interaction is essential for lamellipodial protrusion and cell translocation.,tissue specificity:Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.,
Gene Name
LRRC16A CARMIL LRRC16
Human protein sequence Database
Q5VZK9
Mouse protein sequence database
Q6EDY6
Rat protein sequence database
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane . Cell projection, lamellipodium . Found on macropinosomes (PubMed:19846667). Colocalized with heterodimeric capping protein (CP) and F-actin in lamellipodia but not with F-actin in stress fibers (PubMed:19846667). .
Tissue expression
Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车