Immunogen
Synthesized peptide derived from human FACR2 AA range: 409-459
Specificity
This antibody detects endogenous levels of FACR2 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012],
Function
catalytic activity:Fatty acyl-CoA + 2 NADPH = fatty alcohol + 2 NADP(+).,function:Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.,similarity:Belongs to the fatty acyl-CoA reductase family.,subcellular location:Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein.,
Human protein sequence Database
Q96K12
Mouse protein sequence database
Q7TNT2
Rat protein sequence database
Cellular localization
Peroxisome membrane ; Single-pass membrane protein .
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