Immunogen
Synthesized peptide derived from human RNF4 AA range: 71-121
Specificity
This antibody detects endogenous levels of RNF4 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010],
Function
function:Enhances steroid receptor-mediated transcriptional activation as well as activating basal transcription.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with GSCL, Androgen receptor, TCF20, TBP and PATZ1.,tissue specificity:Widely expressed at low levels in many tissues; highly expressed in testis.,
Gene Name
RNF4 SNURF RES4-26
Human protein sequence Database
P78317
Mouse protein sequence database
Q9QZS2
Rat protein sequence database
O88846
Cellular localization
Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
Tissue expression
Widely expressed at low levels in many tissues; highly expressed in testis.
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