Immunogen
Synthesized peptide derived from human CYBR1 AA range: 41-91
Specificity
This antibody detects endogenous levels of CYBR1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008],
Function
cofactor:Binds 2 heme groups non-covalently.,disease:Defects in CYBRD1 may be a cause of primary hereditary hemochromatosis (HFE). HFE is an iron-loading disorder characterized by iron accumulation in parenchymal cells. Iron accumulation usually results in tissue damage and causes cirrhosis of the liver, diabetes mellitus, arthropathy, cardiomyopathy, endocrine abnormalities and an increased risk of hepatocellular carcinoma.,function:Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.,induction:By iron deficiency (at protein level).,similarity:Contains 1 cytochrom
Gene Name
CYBRD1 DCYTB FRRS3
Fields
>>Mineral absorption
Human protein sequence Database
Q53TN4
Mouse protein sequence database
Q925G2
Rat protein sequence database
Q5RKJ2
Cellular localization
Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Localized at the brush border of duodenal cells. .
Tissue expression
Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.
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