Immunogen
Synthesized peptide derived from human PNCB AA range: 134-184
Specificity
This antibody detects endogenous levels of PNCB at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008],
Function
catalytic activity:Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.,function:Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.,pathway:Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate ribonucleotide from nicotinate: step 1/1.,similarity:Belongs to the NAPRTase family.,
Fields
>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors
Human protein sequence Database
Q6XQN6
Mouse protein sequence database
Q8CC86
Rat protein sequence database
Q6XQN1
Cellular localization
Cytoplasm, cytosol .
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