Immunogen
Synthesized peptide derived from human CMBL AA range: 136-186
Specificity
This antibody detects endogenous levels of CMBL at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010],
Function
similarity:Belongs to the dienelactone hydrolase family.,
Fields
>>Metabolic pathways
Human protein sequence Database
Q96DG6
Mouse protein sequence database
Q8R1G2
Rat protein sequence database
Q7TP52
Cellular localization
Cytoplasm, cytosol .
Tissue expression
Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level).