Immunogen
Synthesized peptide derived from human IL-17 AA range: 50-100
Specificity
This antibody detects endogenous levels of Human IL-17
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;Flow Cyt 1:50-200; ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.,online information:Interleukin-17 entry,PTM:Found both in glycosylated and nonglycosylated forms.,similarity:Belongs to the IL-17 family.,subunit:Homodimer.,tissue specificity:Restricted to activated memory T-cells.,
Function
regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid glycosylation, apoptosis, defense response, inflammatory response, immune response, cell-cell signaling,cell death, glycoprotein metabolic process, glycoprotein biosynthetic process, response to wounding, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, programmed cell death, death, positive regulation of cellular biosynthetic process, biopolymer glycosylation, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA p
Gene Name
IL17A CTLA8 IL17
Other name
Interleukin-17A (IL-17;IL-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA-8)
Fields
>>Cytokine-cytokine receptor interaction;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Alcoholic liver disease;>>Inflammatory bowel disease;>>Rheumatoid arthritis
Human protein sequence Database
Q16552
Mouse protein sequence database
Q62386
Rat protein sequence database
Q61453
Cellular localization
Secreted .
Tissue expression
Expressed in memory Th17 cells (at protein level).
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