Immunogen
Synthesized peptide derived from human U-PAR
Specificity
This antibody detects endogenous levels of Human U-PAR
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.,similarity:Contains 3 UPAR/Ly6 domains.,subunit:Monomer (Probable). Interacts with MRC2.,
Function
protein amino acid lipidation, GPI anchor metabolic process, GPI anchor biosynthetic process, phospholipid metabolic process, glycerophospholipid metabolic process, cell motion, chemotaxis, blood coagulation, hemostasis, behavior,locomotory behavior, lipid biosynthetic process, phospholipid biosynthetic process, response to wounding, attachment of GPI anchor to protein, organophosphate metabolic process, regulation of proteolysis, phosphoinositide metabolic process, regeneration, growth, wound healing, lipoprotein metabolic process, lipoprotein biosynthetic process, tissue regeneration, taxis, skeletal muscle regeneration, glycerolipid biosynthetic process, glycerophospholipid biosynthetic process, glycerolipid metabolic process, phosphoinositide biosynthetic process, developmental growth, coagulation,regulation of body fluid levels,
Other name
Urokinase plasminogen activator surface receptor (U-PAR;uPAR;Monocyte activation antigen Mo3;CD antigen CD87)
Fields
>>Complement and coagulation cascades;>>Proteoglycans in cancer
Human protein sequence Database
Q03405
Mouse protein sequence database
P35456
Rat protein sequence database
P49616
Cellular localization
Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. .; [Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted .
Tissue expression
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
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