Molecular weight (DA)
14,16kD
Immunogen
Synthesized peptide derived from human LC3 A/B
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat LC3 A/B
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
function:Probably involved in formation of autophagosomal vacuoles (autophagosomes).,PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.,similarity:Belongs to the MAP1 LC3 family.,subcellular location:LC3-II binds to the autophagic membranes.,subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.,tissue specificity:Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.,
Function
autophagic vacuole formation, proteolysis, autophagy, vacuole organization, macromolecule catabolic process, cellular response to starvation, response to extracellular stimulus, macroautophagy, modification-dependent protein catabolic process, protein catabolic process, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to stress, response to starvation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process,proteolysis involved in cellular protein catabolic process,
Fields
>>Mitophagy - animal;>>Autophagy - animal;>>Ferroptosis;>>Apelin signaling pathway;>>NOD-like receptor signaling pathway;>>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Kaposi sarcoma-associated herpesvirus infection
Human protein sequence Database
Q9H492/Q9GZQ8
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor . Endomembrane system ; Lipid-anchor . Cytoplasm, cytoskeleton . LC3-II binds to the autophagic membranes. .
Tissue expression
Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
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