Molecular weight (DA)
55 25kD
Immunogen
Synthesized peptide derived from human GSDME. AA range:400-496
Specificity
The antibody detects endogenous full lenth and c-ternal fragment of gsdme protein,
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IF: 1:50-200 WB: 1:5000-20000 IHC: 1:200-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Cleavage at Asp-270 by CASP3 (mature and uncleaved precursor forms) or granzyme B (GZMB) relieves autoinhibition and is sufficient to initiate pyroptosis.
Protein name
Gasdermin-E,DFNA5,Dfna5h,EG14210,2310037D07Rik .4932441K13Rik ,ICERE 1,ICERE-1,Deafness, autosomal dominant 5,Non-syndromic hearing impairment protein 5,GSDME-CT
Human protein sequence Database
O60443
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[Gasdermin-E, N-terminal]: Cell membrane ; Multi-pass membrane protein .; [Gasdermin-E]: Cytoplasm, cytosol .
Tissue expression
Expressed in cochlea (PubMed:9771715). Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta (PubMed:9771715).
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