Immunogen
Synthesized peptide derived from human Ankyrin B
Specificity
This antibody detects endogenous levels of Ankyrin B at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.24% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Other name
Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
Fields
>>Proteoglycans in cancer
Human protein sequence Database
Q01484
Mouse protein sequence database
Q8C8R3
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton . Membrane . Cytoplasm, myofibril, sarcomere, M line . Apical cell membrane . Cell membrane . Cell junction, synapse, postsynaptic cell membrane . Early endosome . Recycling endosome . Lysosome . Mitochondrion . Cytoplasm, myofibril, sarcomere, Z line . Cell membrane, sarcolemma, T-tubule . Expressed at the apical membrane of airway lung epithelial cells (By similarity). Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distinct intracellular compartment of neonatal cardiomyocytes (PubMed:19007774). In skeletal muscle, localizes to neuromuscular junctions (By similarity). Localizes with puncta at mitochondria ends. Colocalizes and cotransports on motile vesicles with RABGAP1L (By similarity). .
Tissue expression
Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina.
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