Immunogen
Synthesized peptide derived from human PLEKHG5
Specificity
This antibody detects endogenous levels of PLEKHG5 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.64% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Gene Name
PLEKHG5 KIAA0720
Other name
Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
Fields
>>Pathways in cancer
Human protein sequence Database
O94827
Mouse protein sequence database
Q66T02
Rat protein sequence database
Q6RFZ7
Cellular localization
Cytoplasm . Cytoplasm, perinuclear region . Cell membrane . Cell junction . Cell projection, lamellipodium . Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane. Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells. .
Tissue expression
Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.
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