Immunogen
Purified recombinant fragment of human KLHL22 expressed in E. Coli.
Specificity
KLHL22 Monoclonal Antibody detects endogenous levels of KLHL22 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,
Function
similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,
Protein name
Kelch-like protein 22
Other name
KLHL22; Kelch-like protein 22
Human protein sequence Database
Q53GT1
Mouse protein sequence database
Q99JN2
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Nucleus . Lysosome . Mainly cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase (PubMed:23455478). Localizes to the nucleus upon amino acid starvation (PubMed:29769719). Relocalizes to the cytosol and associates with lysosomes when amino acids are available (PubMed:29769719). .
Tissue expression
Embryo,Kidney,Liver,
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