Molecular weight (DA)
30kD
Immunogen
Synthesized phosho peptide around human DARPP-32 (Ser97)
Specificity
This antibody detects endogenous levels of Human Mouse Rat DARPP-32 (phospho-Ser97)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Function
function:Inhibitor of protein-phosphatase 1.,PTM:Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.,PTM:Phosphorylation of Thr-34 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family.,
Gene Name
PPP1R1B DARPP32
Protein name
DARPP-32 (Ser97)
Other name
Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein)
Fields
>>cAMP signaling pathway;>>Dopaminergic synapse;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism
Human protein sequence Database
Q9UD71
Mouse protein sequence database
Q60829
Rat protein sequence database
Q6J4I0
Cellular localization
Cytoplasm.
Tissue expression
Adipose tissue,Brain,Cerebellum,Colon,Ovary,
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