Molecular weight (DA)
80kD
Immunogen
Synthesized peptide derived from human Dab1 (Phospho Tyr220)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat Dab1 (Phospho Tyr220)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
domain:The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.,function:Adapter molecule functioning in neural development. May regulate SIAH1 activity.,PTM:Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling.,similarity:Contains 1 PID domain.,subunit:Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.,
Function
neuron migration, cell motion, cell adhesion, negative regulation of cell adhesion, intracellular signaling cascade, small GTPase mediated signal transduction, cell-cell adhesion, cell migration, regulation of phosphate metabolic process, cell migration in hindbrain, telencephalon development, pallium development, cerebellum development, hindbrain morphogenesis, hindbrain structural organization, cerebellum morphogenesis, cerebellum structural organization,cerebral cortex cell migration, cerebral cortex radially oriented cell migration, cerebral cortex radial glia guided migration, neuronal-glial interaction involved in cerebral cortex radial glia guided migration, cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration, forebrain cell migration, hindbrain radial glia guided cell migration, radial glia guided migration of Purkin
Protein name
Dab1 (Phospho Tyr220)
Other name
DAB1; Disabled homolog 1
Fields
>>Spinocerebellar ataxia
Human protein sequence Database
O75553
Mouse protein sequence database
P97318
Rat protein sequence database
Q8CJH2
Tissue expression
Mainly expressed in brain.
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