Molecular weight (DA)
48kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ALS2CR4. AA range:181-230
Specificity
ALS2CR4 Polyclonal Antibody detects endogenous levels of ALS2CR4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Protein name
Transmembrane protein 237
Other name
TMEM237; ALS2CR4; Transmembrane protein 237; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein
Human protein sequence Database
Q96Q45
Mouse protein sequence database
Q3V0J1
Rat protein sequence database
Cellular localization
Membrane ; Multi-pass membrane protein . Cell projection, cilium . Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the transition zone by RPGRIP1L.
Tissue expression
Brain,Fetal skin,Ovary,
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