Molecular weight (DA)
44kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NECAB3. AA range:321-370
Specificity
APBA2BP Polyclonal Antibody detects endogenous levels of APBA2BP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,function:Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid.,PTM:Phosphorylated by NEK2.,similarity:Contains 1 ABM domain.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with the N-terminal domain of APBA2. Interacts with NEK2.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.,
Protein name
N-terminal EF-hand calcium-binding protein 3
Other name
NECAB3; APBA2BP; NIP1; SYTIP2; XB51; N-terminal EF-hand calcium-binding protein 3; Amyloid beta A4 protein-binding family A member 2-binding protein; Nek2-interacting protein 1; Neuronal calcium-binding protein 3; X11L-binding protein 51
Human protein sequence Database
Q96P71
Mouse protein sequence database
Q9D6J4
Rat protein sequence database
Cellular localization
Golgi apparatus .
Tissue expression
Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.
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