Molecular weight (DA)
70kD
Immunogen
Synthesized peptide derived from GABA T-3 . at AA range: 370-450
Specificity
GABA T-3 Polyclonal Antibody detects endogenous levels of GABA T-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
Function
function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,tissue specificity:Widespread distribution in the brain.,
Protein name
Sodium- and chloride-dependent GABA transporter 3
Other name
SLC6A11; GABT3; GAT3; Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 11
Fields
>>Synaptic vesicle cycle;>>GABAergic synapse
Human protein sequence Database
P48066
Mouse protein sequence database
P31650
Rat protein sequence database
P31647
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Widespread distribution in the brain.
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