Molecular weight (DA)
48kD
Immunogen
The antiserum was produced against synthesized peptide derived from human OPRK1. AA range:321-370
Specificity
KOR-1 Polyclonal Antibody detects endogenous levels of KOR-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016],
Function
function:Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.,online information:Kappa opioid receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SLC9A3R1. Interacts with GABARAPL1.,
Protein name
Kappa-type opioid receptor
Other name
OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P41145
Mouse protein sequence database
P33534
Rat protein sequence database
P34975
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Detected in brain and placenta.
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