Molecular weight (DA)
53kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CHRM4. AA range:236-285
Specificity
mAChR M4 Polyclonal Antibody detects endogenous levels of mAChR M4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008],
Function
function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Muscarinic acetylcholine receptor M4
Other name
CHRM4; Muscarinic acetylcholine receptor M4
Fields
>>Neuroactive ligand-receptor interaction;>>Cholinergic synapse;>>Regulation of actin cytoskeleton
Human protein sequence Database
P08173
Mouse protein sequence database
P32211
Rat protein sequence database
P08485
Cellular localization
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
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