Background
NRXN3 (neurexin 3) encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder.
Function
cell morphogenesis, cell morphogenesis involved in differentiation, regulation of neurotransmitter levels, generation of a signal involved in cell-cell signaling, neurotransmitter transport, cell motion, cell adhesion, cell-cell signaling, synaptic transmission, neurotransmitter secretion, axonogenesis, axon guidance, synaptogenesis, transmission of nerve impulse, biological adhesion, cell projection organization, neuron differentiation, neuron projection development,secretion by cell, cellular component morphogenesis, cell part morphogenesis, extracellular structure organization,secretion, neuron development, cell morphogenesis involved in neuron differentiation, neuron projection morphogenesis, cell projection morphogenesis, synapse organization, neurological system process,
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