Molecular weight (DA)
200kD
Immunogen
Synthesized peptide derived from Neuron Navigator 1 . at AA range: 510-590
Specificity
Neuron Navigator 1 Polyclonal Antibody detects endogenous levels of Neuron Navigator 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009],
Function
developmental stage:Expressed in fetal brain and heart.,function:May be involved in neuronal migration.,similarity:Belongs to the Nav/unc-53 family.,subcellular location:Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones.,subunit:Interacts with tubulin.,tissue specificity:Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta.,
Protein name
Neuron navigator 1
Abbreviation
Neuron Navigator 1
Other name
NAV1; KIAA1151; KIAA1213; POMFIL3; STEERIN1; Neuron navigator 1; Pore membrane and/or filament-interacting-like protein 3; Steerin-1; Unc-53 homolog 1; unc53H1
Human protein sequence Database
Q8NEY1
Mouse protein sequence database
Q8CH77
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton . Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity). .
Tissue expression
Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta.
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