Immunogen
Synthesized peptide derived from Neuron Navigator 2 . at AA range: 2040-2120
Specificity
Neuron Navigator 2 Polyclonal Antibody detects endogenous levels of Neuron Navigator 2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Function
alternative products:Additional isoforms may exist,caution:PubMed:15158073 experiments have been carried out in mouse.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart, liver and kidney.,function:Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.,induction:By all-trans retinoic acid (atRA). Up-regulated in colorectal carcinomas.,similarity:Belongs to the Nav/unc-53 family.,similarity:Contains 1 CH (calponin-homology) domain.,tissue specificity:Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expr
Protein name
Neuron navigator 2
Abbreviation
Neuron Navigator 2
Other name
NAV2; HELAD1; KIAA1419; POMFIL2; RAINB1; STEERIN2; Neuron navigator 2; Helicase APC down-regulated 1; Pore membrane and/or filament-interacting-like protein 2; Retinoic acid inducible in neuroblastoma 1; Steerin-2; Unc-53 homolog 2; unc53H2
Human protein sequence Database
Q8IVL1
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.
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