Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TNR16. AA range:121-170
Specificity
NGFR p75 Polyclonal Antibody detects endogenous levels of NGFR p75 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008],
Function
domain:Death domain is responsible for interaction with RANBP9.,domain:The extracellular domain is responsible for interaction with NTRK1.,function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDI
Protein name
Tumor necrosis factor receptor superfamily member 16
Other name
NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Cytokine-cytokine receptor interaction;>>PI3K-Akt signaling pathway;>>Apoptosis - multiple species;>>Neurotrophin signaling pathway;>>Transcriptional misregulation in cancer
Human protein sequence Database
P08138
Mouse protein sequence database
Q9Z0W1
Rat protein sequence database
P07174
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine .
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车