Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NK1R. AA range:211-260
Specificity
NK-1R Polyclonal Antibody detects endogenous levels of NK-1R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008],
Function
function:This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.,online information:Tachykinin entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Substance-P receptor
Other name
TACR1; NK1R; TAC1R; Substance-P receptor; SPR; NK-1 receptor; NK-1R; Tachykinin receptor 1
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P25103
Mouse protein sequence database
P30548
Rat protein sequence database
P14600
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Brain,G-protein coupled receptors,Lung,Placenta,
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