Molecular weight (DA)
43kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NMBR. AA range:221-270
Specificity
NMBR Polyclonal Antibody detects endogenous levels of NMBR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016],
Function
function:Receptor for neuromedin-B.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Neuromedin-B receptor
Other name
NMBR; Neuromedin-B receptor; NMB-R; Epididymis tissue protein Li 185a; Neuromedin-B-preferring bombesin receptor
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P28336
Mouse protein sequence database
O54799
Rat protein sequence database
P24053
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed in epididymis (at protein level).
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