Molecular weight (DA)
48kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NPY1R. AA range:221-270
Specificity
NPY1-R Polyclonal Antibody detects endogenous levels of NPY1-R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013],
Function
function:Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Neuropeptide Y receptor type 1
Other name
NPY1R; NPYR; NPYY1; Neuropeptide Y receptor type 1; NPY1-R
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Regulation of lipolysis in adipocytes
Human protein sequence Database
P25929
Mouse protein sequence database
Q04573
Rat protein sequence database
P21555
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Blood,Brain,Pancreas,Testis,
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