Molecular weight (DA)
43kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SSTR1. AA range:9-58
Specificity
SSTR1 Polyclonal Antibody detects endogenous levels of SSTR1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012],
Function
function:Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SKB1.,tissue specificity:Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.,
Protein name
Somatostatin receptor type 1
Other name
SSTR1; Somatostatin receptor type 1; SS-1-R; SS1-R; SS1R; SRIF-2
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Growth hormone synthesis, secretion and action
Human protein sequence Database
P30872
Mouse protein sequence database
P30873
Rat protein sequence database
P28646
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
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