Molecular weight (DA)
67kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human VGF. AA range:451-500
Specificity
VGF Polyclonal Antibody detects endogenous levels of VGF protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008],
Function
function:May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.,subcellular location:Stored in secretory vesicles and then secreted.,tissue specificity:Expressed in brain.,
Protein name
Neurosecretory protein VGF
Other name
VGF; Neurosecretory protein VGF
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
O15240
Mouse protein sequence database
Rat protein sequence database
P20156
Cellular localization
[Neurosecretory protein VGF]: Secreted . Cytoplasmic vesicle, secretory vesicle . Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
Tissue expression
Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
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