Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human SLC6A1. AA range:170-220
Specificity
The antibody detects endogenous GABA T-1
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009],
Function
domain:The PDZ domain-binding motif is involved in the interaction with MPP5.,function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subcellular location:Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons.,subunit:Interacts with MPP5.,
Gene Name
SLC6A1 GABATR GABT1 GAT1
Protein name
Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)
Other name
Sodium- and chloride-dependent GABA transporter 1 (GAT-1;Solute carrier family 6 member 1)
Fields
>>Synaptic vesicle cycle;>>GABAergic synapse
Human protein sequence Database
P30531
Mouse protein sequence database
P31648
Rat protein sequence database
P23978
Cellular localization
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell junction, synapse, presynapse . Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). .
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