Molecular weight (DA)
125kD
Immunogen
The antiserum was produced against synthesized peptide derived from human IL-3R beta around the phosphorylation site of Tyr593. AA range:559-608
Specificity
Phospho-IL-3Rβ (Y593) Polyclonal Antibody detects endogenous levels of IL-3Rβ protein only when phosphorylated at Y593.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008],
Function
disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,
Protein name
Cytokine receptor common subunit beta
Other name
CSF2RB; IL3RB; IL5RB; Cytokine receptor common subunit beta; CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD antigen CD131
Fields
>>Cytokine-cytokine receptor interaction;>>Apoptosis;>>JAK-STAT signaling pathway;>>Pathways in cancer
Human protein sequence Database
P32927
Mouse protein sequence database
P26955
Rat protein sequence database
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
Placenta,
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