Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ADORA2A. AA range:120-169
Specificity
Adenosine A2A-R Polyclonal Antibody detects endogenous levels of Adenosine A2A-R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
adenosine A2a receptor(ADORA2A) Homo sapiens This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript compos
Function
function:Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Adenosine receptor A2a
Abbreviation
Adenosine A2A-R
Other name
ADORA2A; ADORA2; Adenosine receptor A2a
Fields
>>Rap1 signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction;>>Parkinson disease;>>Alcoholism
Human protein sequence Database
P29274
Mouse protein sequence database
Q60613
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Colocalizes with GAS2L2 at neuronal processes. .
Tissue expression
Brain,Hippocampus,Lymph,Thymus,
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