Molecular weight (DA)
44kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CCKAR. AA range:215-264
Specificity
CCK-AR Polyclonal Antibody detects endogenous levels of CCK-AR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008],
Function
function:Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Cholecystokinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Cholecystokinin receptor type A
Other name
CCKAR; CCKRA; Cholecystokinin receptor type A; CCK-A receptor; CCK-AR; Cholecystokinin-1 receptor; CCK1-R
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Insulin secretion;>>Pancreatic secretion
Human protein sequence Database
P32238
Mouse protein sequence database
O08786
Rat protein sequence database
P30551
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Gall bladder,Peripheral blood leukocyte,Stomach,
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