Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PE2R2. AA range:261-310
Specificity
EP2 Polyclonal Antibody detects endogenous levels of EP2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009],
Function
function:Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Placenta and lung.,
Protein name
Prostaglandin E2 receptor EP2 subtype
Other name
PTGER2; Prostaglandin E2 receptor EP2 subtype; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostanoid EP2 receptor
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Inflammatory mediator regulation of TRP channels;>>Renin secretion;>>Human cytomegalovirus infection;>>Pathways in cancer
Human protein sequence Database
P43116
Mouse protein sequence database
Q62053
Rat protein sequence database
Q62928
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Placenta and lung.
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