Molecular weight (DA)
77kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ELTD1. AA range:251-300
Specificity
ETL Polyclonal Antibody detects endogenous levels of ETL protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
developmental stage:Up-regulated in the adult heart.,domain:The transmembrane domain is not required for cleavage, but it is required for dimer formation.,function:Could be involved in cardiac development.,PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 2 EGF-like domains.,subunit:Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface.,tissue specificity:Mainly expressed in smooth muscle.,
Function
developmental stage:Up-regulated in the adult heart.,domain:The transmembrane domain is not required for cleavage, but it is required for dimer formation.,function:Could be involved in cardiac development.,PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 2 EGF-like domains.,subunit:Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface.,tissue specificity:Mainly expressed in smooth muscle.,
Protein name
EGF latrophilin and seven transmembrane domain-containing protein 1
Other name
ELTD1; ETL; EGF; latrophilin and seven transmembrane domain-containing protein 1; EGF-TM7-latrophilin-related protein; ETL protein
Human protein sequence Database
Q9HBW9
Mouse protein sequence database
Q923X1
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Detected in the majority of epithelial cells in tumor and normal tissues. Expressed also in human umbilical vein endothelial cells.
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