Molecular weight (DA)
54kD
Immunogen
Synthesized peptide derived from FGFR-5 . at AA range: 130-210
Specificity
FGFR-5 Polyclonal Antibody detects endogenous levels of FGFR-5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other
Function
function:Has a negative effect on cell proliferation.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.,subunit:Interacts with FGF2 with a low affinity.,tissue specificity:Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.,
Protein name
Fibroblast growth factor receptor-like 1
Other name
FGFRL1; FGFR5; FHFR; Fibroblast growth factor receptor-like 1; FGF receptor-like protein 1; FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5; FGFR-5
Human protein sequence Database
Q8N441
Mouse protein sequence database
Q91V87
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type I membrane protein . Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
Tissue expression
Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.
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