Molecular weight (DA)
100kD
Immunogen
The antiserum was produced against synthesized peptide derived from human LGR4. AA range:461-510
Specificity
GPR48 Polyclonal Antibody detects endogenous levels of GPR48 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016],
Function
function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 15 LRR (leucine-rich) repeats.,tissue specificity:Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.,
Protein name
Leucine-rich repeat-containing G-protein coupled receptor 4
Other name
LGR4; GPR48; Leucine-rich repeat-containing G-protein coupled receptor 4; G-protein coupled receptor 48
Fields
>>Wnt signaling pathway
Human protein sequence Database
Q9BXB1
Mouse protein sequence database
A2ARI4
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.
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