Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HRH1. AA range:141-190
Specificity
Histamine H1 Receptor Polyclonal Antibody detects endogenous levels of Histamine H1 Receptor protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by Ref
Function
function:In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.,PTM:Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal transduction through the receptor molecule.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
Histamine H1 receptor
Abbreviation
Histamine H1 Receptor
Other name
HRH1; Histamine H1 receptor; H1R; HH1R
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Inflammatory mediator regulation of TRP channels
Human protein sequence Database
P35367
Mouse protein sequence database
P70174
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Lens epithelium,Lung,
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