Molecular weight (DA)
104kD
Immunogen
The antiserum was produced against synthesized peptide derived from human LGR6. AA range:471-520
Specificity
LGR6 Polyclonal Antibody detects endogenous levels of LGR6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],
Function
function:Orphan receptor.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 16 LRR (leucine-rich) repeats.,
Protein name
Leucine-rich repeat-containing G-protein coupled receptor 6
Other name
LGR6; Leucine-rich repeat-containing G-protein coupled receptor 6
Fields
>>Wnt signaling pathway
Human protein sequence Database
Q9HBX8
Mouse protein sequence database
Q3UVD5
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Mammary gland,
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