Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human LTBR. AA range:11-60
Specificity
LTβR Polyclonal Antibody detects endogenous levels of LTβR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
lymphotoxin beta receptor(LTBR) Homo sapiens This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012],
Function
function:Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein.,
Protein name
Tumor necrosis factor receptor superfamily member 3
Other name
LTBR; D12S370; TNFCR; TNFR3; TNFRSF3; Tumor necrosis factor receptor superfamily member 3; Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type II
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>NF-kappa B signaling pathway;>>HIF-1 signaling pathway;>>Intestinal immune network for IgA production;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis
Human protein sequence Database
P36941
Mouse protein sequence database
P50284
Rat protein sequence database
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
Liver,Lung,
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