Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MC5R. AA range:271-320
Specificity
MC5-R Polyclonal Antibody detects endogenous levels of MC5-R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010],
Function
function:Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.,online information:Melanocortin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in the brain but not in the melanoma cells.,
Protein name
Melanocortin receptor 5
Other name
MC5R; Melanocortin receptor 5; MC5-R; MC-2
Fields
>>Neuroactive ligand-receptor interaction
Human protein sequence Database
P33032
Mouse protein sequence database
P41149
Rat protein sequence database
P35345
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Expressed in the brain but not in the melanoma cells.
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