Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from human OR51E2. AA range:221-270
Specificity
PSGR Polyclonal Antibody detects endogenous levels of PSGR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008],
Function
function:Odorant receptor .,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Exclusively expressed in the prostate. Up-regulated in prostate cancers.,
Protein name
Olfactory receptor 51E2
Other name
OR51E2; PSGR; Olfactory receptor 51E2; HPRAJ; Olfactory receptor OR11-16; Prostate-specific G-protein coupled receptor
Fields
>>Olfactory transduction
Human protein sequence Database
Q9H255
Mouse protein sequence database
Rat protein sequence database
O88628
Cellular localization
Cell membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein .
Tissue expression
Highly expressed in the prostate (PubMed:11707321). Also expressed in spleen, liver, olfactory epithelium, retinal pigment epithelium and medulla oblongata (PubMed:29249973, PubMed:11707321, PubMed:16491480). In the retinal pigment epithelium expression is restricted to the pigment cells and choroid (at protein level) (PubMed:29249973). Expressed in epidermal melanocytes (at protein level) (PubMed:27226631).
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