Molecular weight (DA)
46kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RELT. AA range:381-430
Specificity
RELT Polyclonal Antibody detects endogenous levels of RELT protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008],
Function
function:Mediates activation of NF-kappa-B. May play a role in T-cell activation.,PTM:Phosphorylated in vitro by OXSR1.,similarity:Belongs to the RELT family.,similarity:Contains 1 TNFR-Cys repeat.,subunit:Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1.,tissue specificity:Highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in brain, kidney and pancreas.,
Protein name
Tumor necrosis factor receptor superfamily member 19L
Other name
RELT; TNFRSF19L; Tumor necrosis factor receptor superfamily member 19L; Receptor expressed in lymphoid tissues
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
Q969Z4
Mouse protein sequence database
Q8BX43
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Cytoplasm, perinuclear region .
Tissue expression
Spleen, lymph node, brain, breast and peripheral blood leukocytes (at protein level) (PubMed:28688764). Expressed highly in bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in kidney and pancreas.
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