Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TAS2R43. AA range:124-173
Specificity
T2R43 Polyclonal Antibody detects endogenous levels of T2R43 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009],
Function
function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.,
Protein name
Taste receptor type 2 member 43
Other name
TAS2R43; Taste receptor type 2 member 43; T2R43; Taste receptor type 2 member 52; T2R52
Fields
>>Taste transduction
Human protein sequence Database
P59537
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane ; Multi-pass membrane protein . Cell projection, cilium membrane . In airway epithelial cells, localizes to motile cilia.
Tissue expression
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in airway epithelia.
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