Molecular weight (DA)
41kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TMEM185A. AA range:290-339
Specificity
TMEM185A Polyclonal Antibody detects endogenous levels of TMEM185A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013],
Function
similarity:Belongs to the TMEM185 family.,
Protein name
Transmembrane protein 185A
Other name
TMEM185A; CXorf13; FAM11A; Transmembrane protein 185A; Protein FAM11A
Human protein sequence Database
Q8NFB2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell projection, dendrite . Membrane ; Multi-pass membrane protein .
Tissue expression
Brain,Iris,Liver,PCR rescued clones,Testis,
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