Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human AVPR1B. AA range:271-320
Specificity
The antibody detects endogenous AVP Receptor V3
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008],
Function
function:Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Gene Name
AVPR1B AVPR3 VPR3
Protein name
Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor)
Abbreviation
AVP Receptor V3
Other name
Vasopressin V1b receptor (V1bR;AVPR V1b;AVPR V3;Antidiuretic hormone receptor 1b;Vasopressin V3 receptor)
Fields
>>Calcium signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction
Human protein sequence Database
P47901
Mouse protein sequence database
Q9WU02
Rat protein sequence database
P48974
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Lung carcinoma,Pituitary,
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